Search on: TOSYLPHENYLALANYL CHLOROMETHYL KETONE 
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Descriptor English:   Tosylphenylalanyl Chloromethyl Ketone 
Descriptor Spanish:   Clorometilcetona de Tosilfenilalanila 
Descriptor Portuguese:   Tosilfenilalanil Clorometil Cetona 
Synonyms English:   Chloromethane, Tosylphenylalanyl
Chloromethyl Ketone, Tosylphenylalanyl
Chlorophenyltosylamidobutanone
Ketone, Tosylphenylalanyl Chloromethyl
TPCK
Tosylphenylalanyl Chloromethane  
Tree Number:   D02.455.426.559.389.832.710
D02.886.590.887.660
D12.125.065.930
Definition English:   An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process. 
Pharmacological Action:   Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
 
History Note English:   91(75); was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   14500 
Unique Identifier:   D014108 

Occurrence in VHL:
 

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